Dr. Farouc JAFFER
Director of Vascular Imaging in the Cardiovascular Molecular Imaging Program at Massachusetts General Hospital, Harvard Medical School. Attending Interventional Cardiologist at Massachusetts General Hospital

Dr. Jaffer's laboratory developing molecular imaging technology and solutions to understand the biology of atherosclerosis and thrombosis in vivo. A primary focus of the laboratory is the development of MRI, optical (fluorescence), and integrated nuclear–computed tomography (SPECT/CT, PET/CT) approaches to illuminate important molecular and cellular aspects of vascular disease, including protease activity, cellular inflammation, and transglutaminase activity. The laboratory works closely with the Center for Molecular Imaging Research, a world-renowned center for small animal imaging and the synthesis of novel nanomaterials. In addition to investigating in vivo biology in genetically- or pharmacologically-altered mouse models of cardiovascular disease, his group is developing promising imaging agents for large animal translation using noninvasive MRI as well as novel catheter-based and noninvasive near infrared fluorescence (NIRF) technology. Successful imaging agents will be investigated in phase I/II clinical trials to evaluate their utility for diagnostic imaging and to provide surrogate endpoints for assessing novel pharmaceuticals.